SELECTED PUBLICATIONS
2021
Liting Hang, Ziyin Wang, Aaron S C Foo, Geraldine W Y Goh, Huey Ching Choong, John Thundyil, Shengli Xu, Kong-Peng Lam, Kah-Leong Lim. "Conditional disruption of AMP kinase in dopaminergic neurons promotes Parkinson's disease-associated phenotypes in vivo." Neurobiology of Disease 161 (2021): 105560. [Link]
Junghyun Jo, Lin Yang, Hoang-Dai Tran, Weonjin Yu, Alfred Xuyang Sun, Ya Yin Chang, Byung Chul Jung, Seung-Jae Lee, Tzuen Yih Saw, Bin Xiao, Audrey Tze Ting Khoo, Lai-Ping Yaw, Jessica Jiaxin Xie, Hidayat Lokman, Wei-Yi Ong, Grace Gui Yin Lim, Kah-Leong Lim, Eng-King Tan, Huck-Hui Ng, Hyunsoo Shawn Je. "Lewy Body-like Inclusions in Human Midbrain Organoids Carrying Glucocerebrosidase and α-Synuclein Mutations." Annals of Neurology 90, no. 3 (2021): 490-505. [Link]
Saravanan Gunaseelan, Ziyin Wang, Venetia Kok Jing Tong, Sylvester Wong Shu Ming, Rafhanah Banu Bte Abdul Razar, Sumitra Srimasorn, Wei-Yi Ong, Kah-Leong Lim, John Jia En Chua. "Loss of FEZ1, a gene deleted in Jacobsen syndrome, causes locomotion defects and early mortality by impairing motor neuron development." Human Molecular Genetics 30, no. 1 (2021): 5-20. [Link]
2020
Daniel Boon Loong Teh, Akshaya Bansal, Chou Chai, Tan Boon Toh, Robert Alan Jappy Tucker, Gil Gerald Lasam Gammad, Yanzhuang Yeo, Zhendong Lei, Xiang Zheng, Fengyuan Yang, John S Ho, Nagarjun Bolem, Bing Cheng Wu, Muthu Kumar Gnanasammandhan, Lissa Hooi, Gavin Stewart Dawe, Camilo Libedinsky, Wei-Yi Ong, Barry Halliwell, Edward Kai-Hua Chow, Kah-Leong Lim, Yong Zhang, Brian K Kennedy. "A Flexi-PEGDA Upconversion Implant for Wireless Brain Photodynamic Therapy." Advanced Materials 32, no. 29 (2020): e2001459. [Link]
Aaron Song Chuan Foo, Tuck Wah Soong, Tseng Tsai Yeo, and Kah-Leong Lim. "Mitochondrial Dysfunction and Parkinson’s Disease—Near-Infrared Photobiomodulation as a Potential Therapeutic Strategy." Frontiers in Aging Neuroscience 12 (2020): 89. [Link]
Joan Poh Ling Sim, Wang Ziyin, Adeline Henry Basil, Shuping Lin, Zhongcan Chen, Chengwu Zhang, Li Zeng, Yu Cai, Kah-Leong Lim. "Identification of PP2A and S6 Kinase as Modifiers of Leucine-Rich Repeat Kinase-Induced Neurotoxicity." Neuromolecular Medicine 22, no. 2 (2020): 218-226. [Link]
2019
Yun Ni, Hang Zhang, Chou Chai, Bo Peng, Ang Zhao, Jie Zhang, Lin Li, Chengwu Zhang, Bo Ma, Hua Bai, Kah-Leong Lim, Wei Huang. "Mitochondria-Targeted Two-Photon Fluorescent Photosensitizers for Cancer Cell Apoptosis via Spatial Selectability." Advanced Healthcare Materials 8, no. 14 (2019): e1900212. [Link]
Liting Hang, John Thundyil, Geraldine W Y Goh, Kah-Leong Lim. "AMP Kinase Activation is Selectively Disrupted in the Ventral Midbrain of Mice Deficient in Parkin or PINK1 Expression." Neuromolecular Medicine 21, no. 1 (2019): 25-32. [Link]
2018
Chao Liu, Cheng-Wu Zhang, Shun Qiang Lo, Seok Ting Ang, Katherine Chee Meng Chew, Dejie Yu, Bing Han Chai, Bobby Tan, Fai Tsang, Yee Kit Tai, Bryce Wei Quan Tan, Mui Cheng Liang, Hwee Tong Tan, Jia Ying Tang, Mitchell Kim Peng Lai, John Jia En Chua, Maxey Ching Ming Chung, Sanjay Khanna, Kah-Leong Lim, Tuck Wah Soong. "S-Nitrosylation of Divalent Metal Transporter 1 Enhances Iron Uptake to Mediate Loss of Dopaminergic Neurons and Motoric Deficit." The Journal of Neuroscience 38, no. 39 (2018): 8364-8377. [Link]
Kenneth K. B. Tan, Wallie Wee Meng Lim, Chou Chai, Marek Kukumberg, Kah Leong Lim, Eyleen L. K. Goh & Evelyn K. F. Yim. "Sequential Application of Discrete Topographical Patterns Enhances Derivation of Functional Mesencephalic Dopaminergic Neurons from Human Induced Pluripotent Stem Cells." Scientific Reports 8 (2018): 9567. [Link]
2017
Adeline H Basil, Joan P L Sim, Grace G Y Lim, Shuping Lin, Hui Ying Chan, Simone Engelender, Kah-Leong Lim. "AF-6 Protects Against Dopaminergic Dysfunction and Mitochondrial Abnormalities in Drosophila Models of Parkinson's Disease." Frontiers in Cellular Neuroscience 11 (2017): 241. [Link]
Cheng-Wu Zhang, Yee Kit Tai, Bing-Han Chai, Katherine C M Chew, Eng-Tat Ang, Fai Tsang, Bryce W Q Tan, Eugenia T E Hong, Abu Bakar Ali Asad, Kai-Hsiang Chuang, Kah-Leong Lim, Tuck Wah Soong. "Transgenic Mice Overexpressing the Divalent Metal Transporter 1 Exhibit Iron Accumulation and Enhanced Parkin Expression in the Brain." Neuromolecular Medicine 19, no. 2-3 (2017): 375-386. [Link]
Chee-Hoe Ng, Liting Hang, and Kah-Leong Lim. "Mitochondrial homeostasis in Parkinson’s disease - a triumvirate rule?." Neural Regeneration Research 12, no. 8 (2017): 1270–1272. [Link]
Lim, Grace GY, and Kah‐Leong Lim. "Parkin‐independent mitophagy—FKBP8 takes the stage." EMBO reports 18, no. 6 (2017): 864-865. [Link]
Chee-Hoe Ng, Adeline H Basil, Liting Hang, Royston Tan, Kian-Leong Goh, Sharon O'Neill, Xiaodong Zhang, Fengwei Yu, Kah-Leong Lim. "Genetic or pharmacological activation of the Drosophila PGC-1α ortholog spargel rescues the disease phenotypes of genetic models of Parkinson's disease." Neurobiology of Aging 55 (2017): 33-37. [Link]
2016
Hang, Liting, Adeline Henry Basil, and Kah-Leong Lim. "Nutraceuticals in Parkinson’s disease." Neuromolecular medicine 18, no. 3 (2016): 306-321. [Link]
Chai, Chou, Ru Ong, Cheng Zhang, Bing Chai, Li Qiu, Moogaambikai Thangaveloo, Dejie Yu et al. "Umbilical cord lining-derived induced pluripotent stem cells as a novel source for cell replacement therapy of Parkinson's disease." Movement Disorders 31 (2016): S64.
Nucifora Jr, Frederick C., Leslie G. Nucifora, Chee-Hoe Ng, Nicolas Arbez, Yajuan Guo, Elaine Roby, Vered Shani et al. "Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1." Nature communications 7 (2016). [Link]
Zhang, Cheng-Wu, Henry Basil Adeline, Bing-Han Chai, Eugenia TE Hong, Chee-Hoe Ng, and Kah-Leong Lim. "Pharmacological or Genetic Activation of Hsp70 Protects against Loss of Parkin Function." Neurodegenerative Diseases 16, no. 5-6 (2016): 304-316. [Link]
Sharan, Priyankan, Dario C. Angeles, Patrick Ho, Brian W. Dymock, Kah-Leong Lim, and Eng-King Tan. "Antioxidant kinase inhibitors for LRRK2 Parkinson's disease." Parkinsonism & Related Disorders 22 (2016): e166-e167. [Link]
2015
Li, Lin, Cheng‐Wu Zhang, Jingyan Ge, Linghui Qian, Bing‐Han Chai, Qing Zhu, Jun‐Seok Lee, Kah‐Leong Lim, and Shao Q. Yao. "A Small‐Molecule Probe for Selective Profiling and Imaging of Monoamine Oxidase B Activities in Models of Parkinson’s Disease." Angewandte Chemie International 54, no. 37 (2015): 10821-10825. [Link]
Lim, Grace GY, Doreen SK Chua, Adeline H. Basil, Hui-Ying Chan, Chou Chai, Thiruma Arumugam, and Kah-Leong Lim. "Cytosolic PTEN-induced Putative Kinase 1 Is Stabilized by the NF-κB Pathway and Promotes Non-selective Mitophagy." Journal of Biological Chemistry 290, no. 27 (2015): 16882-16893. [Link]
Hang, Liting, John Thundyil, and Kah‐Leong Lim. "Mitochondrial dysfunction and Parkinson disease: a Parkin–AMPK alliance in neuroprotection." Annals of the New York Academy of Sciences 1350, no. 1 (2015): 37-47. [Link]
Norris, Kristi L., Rui Hao, Liang-Fu Chen, Chun-Hsiang Lai, Meghan Kapur, Peter J. Shaughnessy, Dennis Chou et al. "Convergence of Parkin, PINK1, and α-synuclein on stress-induced mitochondrial morphological remodeling." Journal of Biological Chemistry 290, no. 22 (2015): 13862-13874. [Link]
2014
Lu, Hong Fang, Chou Chai, Tze Chiun Lim, Meng Fatt Leong, Jia Kai Lim, Shujun Gao, Kah Leong Lim, and Andrew CA Wan. "A defined xeno-free and feeder-free culture system for the derivation, expansion and direct differentiation of transgene-free patient-specific induced pluripotent stem cells." Biomaterials 35, no. 9 (2014): 2816-2826. [Link]
Li, Lin, Cheng-Wu Zhang, Grace YJ Chen, Biwei Zhu, Chou Chai, Qing-Hua Xu, Eng-King Tan, Qing Zhu, Kah-Leong Lim, and Shao Q. Yao. "A sensitive two-photon probe to selectively detect monoamine oxidase B activity in Parkinson’s disease models." Nature communications 5 (2014). [Link]
Zhang, Heng, Yan Wang, Jack Jing Lin Wong, Kah-Leong Lim, Yih-Cherng Liou, Hongyan Wang, and Fengwei Yu. "Endocytic pathways downregulate the L1-type cell adhesion molecule neuroglian to promote dendrite pruning in Drosophila." Developmental cell 30, no. 4 (2014): 463-478. [Link]